Researchstructural proteomicsalzheimersmass spectrometry
Scripps Researchers Identify Plasma Protein Structural Biomarkers
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Scientists at Scripps Research report in Nature Aging on February 27, 2026, a blood-based assay that measures structural exposure at specific sites on plasma proteins and classifies 520 individuals as cognitively normal, mild cognitive impairment (MCI), or Alzheimer's with about 83% overall accuracy and over 93% in two-way comparisons. The three-marker panel (C1QA, clusterin, apolipoprotein B) tracked status over months and may enable earlier diagnosis and progression monitoring.
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