Periventricular WMH Predicts Accelerated Cognitive Decline

Researchers led by IISER Berhampur published in November 2025 in Cerebral Cortex report that periventricular white-matter hyperintensity (WMH) burden above ~2.5 mL marks a tipping point where brain tissue loss and cognitive inefficiency accelerate. Using multinational cohorts including ADNI and the US National Alzheimer’s Coordinating Center, the study links elevated WMH to slowed reaction time and multitasking deficits, supporting earlier MRI monitoring and vascular-risk management.