Slow Migration Eradicates Cooperative Antimicrobial Resistance
Hernández-Navarro et al. (published March 16, 2026) model antimicrobial resistance dynamics across a two-dimensional metapopulation of demes subject to time-varying environments and migration. They show that slow-but-nonzero migration combined with environmental fluctuations and demographic bottlenecks increases extinction probability of cooperative resistant strains and can accelerate resistance clearance. The work identifies near-optimal fluctuation timescales and migration rates and provides analytical and simulation guidance for laboratory tests.
Scoring Rationale
Strong novel theoretical insight with experimental guidance, limited to modeling assumptions and specific metapopulation scenarios.
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