Plastic Stabilizers Promote Breast Cancer Progression
Researchers (Huo et al.) published March 6, 2026 in PLoS Computational Biology report that exposure to common plastic stabilizers 2,6-DTB, TBHQ, and UV-328 associates with breast cancer progression. Using network toxicology, LASSO/SVM selection of 69 candidate genes reduced to five core targets (GSK3B, MAPK14, PARP1, PIM1, TRDMT1); molecular docking, MD simulations, and in vitro assays show PSs bind and upregulate MAPK14/PIM1/TRDMT1, promoting proliferation and migration.
Scoring Rationale
Strong computational and experimental evidence supports mechanistic link, but findings are preclinical and limited to three stabilizers.
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