Researchnetwork toxicologymolecular dockingbreast cancerplastic stabilizers
Plastic Stabilizers Promote Breast Cancer Progression
7.3
Relevance ScoreResearchers (Huo et al.) published March 6, 2026 in PLoS Computational Biology report that exposure to common plastic stabilizers 2,6-DTB, TBHQ, and UV-328 associates with breast cancer progression. Using network toxicology, LASSO/SVM selection of 69 candidate genes reduced to five core targets (GSK3B, MAPK14, PARP1, PIM1, TRDMT1); molecular docking, MD simulations, and in vitro assays show PSs bind and upregulate MAPK14/PIM1/TRDMT1, promoting proliferation and migration.
