Review Calls For Global MIC Standardization

A review published in New Contaminants warns that inconsistent MIC breakpoint interpretation between CLSI and EUCAST undermines environmental antimicrobial resistance surveillance and clinical decision-making. The authors note differing ciprofloxacin breakpoints for Escherichia coli can reclassify isolates between susceptible and resistant, and they call for globally harmonized MIC breakpoints to improve data comparability, treatment guidance, and early detection of resistance trends.