Researchcryo emstructural biologyvaccinologyhantavirus
Researchers Reveal Andes Virus Gn-Gc Structure
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8.3
Researchers at The University of Texas at Austin report in Cell that they solved the Andes hantavirus Gn-Gc tetramer structure at 2.3-angstrom resolution and created a vaccine candidate that elicited neutralizing antibodies in mice. Using cryo-electron microscopy on virus-like particles and selective particle orientation, the study corrects prior 12-Å models and provides an atomic blueprint to guide stabilizing mutations and antibody design.
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