Mass General Brigham Spins Out AIwithCare Startup

Mass General Brigham announces the spinout of AIwithCare, founded by system researchers who built RECTIFIER, a RAG-based AI screening tool. RECTIFIER doubled enrollment versus manual screening in a nearly 4,500‑patient randomized trial published in JAMA (2025) and supports more than 20 active use cases across specialties. AIwithCare plans to scale the platform to other health systems to streamline trial matching and operational analytics.
Key Points
- 1Deploys RECTIFIER RAG tool that doubled enrollment versus manual screening in a randomized 4,500‑patient trial.
- 2Demonstrates scalable accuracy across specialties with over 20 active cases in cardiology, oncology, neurology, and more.
- 3Enables practitioners to cut manual chart review time and cost, improving trial matching and recruitment efficiency.
Scoring Rationale
Strong clinical trial evidence and commercialization drive impact; limited primarily to healthcare trial recruitment applications.
Sources
Public references used for this report.
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