Machine Learning Predicts Stroke Mortality Risk
A systematic review and meta-analysis published April 2, 2026, evaluated 68 studies (75 models, 43 external validations) up to June 23, 2025 on machine learning models predicting stroke mortality. Pooled external-validation C-indexes were 0.727 for in-hospital mortality and 0.847 for out-of-hospital mortality, with sensitivities ~0.64–0.71 and specificities ~0.74–0.76. Substantial heterogeneity and elevated risk of bias limit immediate clinical deployment; external validation is recommended.
Key Points
- 1Pooled data from 68 studies (75 models, 43 validations) show 0.727 in-hospital C-index.
- 2Out-of-hospital models had higher discrimination (C-index 0.847), indicating stronger long-term prediction.
- 3Recommend external validation and cautious deployment due to heterogeneity, bias, and variable time performance.
Scoring Rationale
This peer-reviewed systematic meta-analysis presents novel, credible evidence on ML performance for stroke mortality (high novelty and credibility). Score reflects strong relevance and useful insights, but scope is stroke-specific and practical actionability is limited by substantial heterogeneity and risk of bias, so deployment requires external validation.
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