Ensemble Model Predicts Pharmacogenetic Testing Uptake

Researchers at the University of Florida develop and validate machine learning models to predict patients' likelihood of undergoing pharmacogenetic testing when prescribed opioids, using EHR data from 48,528 patients and multiple classifiers. An ensemble combining XGBoost and SVM achieved a 79.61% C-statistic and 67.4% accuracy, with age, hypertension, and household income as top predictors, suggesting a decision-support role to guide testing outreach and resource allocation.