Anthrax Nanopore Enables High-Fidelity Single-Peptide Classification
Researchers Bryan A. Krantz and Jennifer M. Colby publish Feb. 19, 2026 in PLOS Computational Biology demonstrating a dynamical anthrax protective antigen (PA) nanopore that classifies single peptide translocation events with ~91% accuracy. The PA pore’s dynamic active-site clamps produce multi-state, information-rich ionic current signatures and permit analysis at low nanomolar concentrations. This advance supports single-molecule proteomics in complex mixtures without ensemble averaging.
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