TCR2HLA Infers HLA Genotypes From Repertoires
Researchers published TCR2HLA on January 16, 2026, an open-source tool that infers HLA genotypes from TCRβ repertoires. Using four TCRβseq datasets (3,150 individuals, ~71 million TCRs) they identified ~96,000 HLA-associated TCRβ features and trained classifiers with balanced accuracy >0.9 for several common HLA-A, B, C, DRB1 and class II alleles; calibrated predictions support samples with as few as 5,000 unique clonotypes.
Key Points
- 1Discovers ~96,000 TCRβ features from 71 million sequences enriched for specific HLA alleles
- 2Achieves balanced accuracy >0.9 across multiple common HLA-A, B, C, DRB1 and class II alleles
- 3Enables calibrated genotype imputation from small repertoires and discovery of exposure-associated TCR biomarkers
Scoring Rationale
High methodological novelty and broad applicability with peer-reviewed validation; limited by incremental advance over prior HLA‑TCR mapping work.
Sources
Public references used for this report.
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