Study Identifies Two Biological Pathways In MS

Researchers at University College London and Queen Square Analytics publish a study in Brain analyzing combined MRI and serum neurofilament light chain (sNfL) data from 634 people with MS, identifying two distinct biological subtypes. One subtype shows early cortical damage and slower decline, while the other shows predominant white-matter degeneration and faster progression. The split may explain variable treatment responses and enable earlier biology-driven patient stratification.