SeekRBP Improves RBP Identification For Phages
Researchers present SeekRBP, a sequence–structure framework submitted to arXiv on 5 March 2026 that detects receptor-binding proteins (RBPs) using a multi-armed bandit negative-sampling strategy and multimodal protein language plus structural embeddings. Benchmarks show SeekRBP outperforms static sampling approaches, and a Vibrio phage case study demonstrates improved host prediction, suggesting utility for large-scale annotation and synthetic biology applications.
Key Points
- 1Introduces SeekRBP using bandit-based negative sampling and multimodal protein-structure embeddings
- 2Addresses class imbalance and hard-negative selection improving RBP detection accuracy and generalization
- 3Enables more accurate phage host prediction and scalable RBP annotation for synthetic biology workflows
Scoring Rationale
Strong methodological innovation and practical gains drive score, limited by preprint status and constrained evaluation scope.
Sources
Public references used for this report.
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