scPilot Enables Omics-Native Reasoning For Single-Cell

Researchers (Gao et al.) on Feb. 12, 2026 present scPilot, a framework that lets LLMs directly inspect single-cell RNA-seq data and use bioinformatics tools to perform annotation, trajectory reconstruction, and TF targeting. They release scBench, nine curated datasets and graders, and report iterative reasoning improves cell-type accuracy by 11% and reduces trajectory graph-edit distance by 30%, enabling auditable, interpretable analyses.