Researchalphafold2 multimerprotein protein interactionsintrinsically disordered regions
Predicted Interactome Reveals Binding Interference From Disordered Regions
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8.8
Peng and Zhao (published January 22, 2026) used AlphaFold2-multimer to predict protein-protein interactions in Drosophila melanogaster from physical and functional datasets. They report that incorporating functional associations increases high-confidence predictions and reveal intrinsically disordered regions frequently mediate or interfere with binding; authors provide data, code, and a web interface for exploration.
Scoring Rationale
High-quality, peer-reviewed proteome-scale AlphaFold2 multimer predictions and a public resource; overall novelty modest, focused on Drosophila-specific application.
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