Physical Models Explain Embryonic Epithelial Healing

Almada, Araújo and Patrício publish a March 25, 2026 PLoS Computational Biology review surveying physical models of embryonic epithelial wound healing, from discrete cell-based to continuum approaches. They synthesize mechanisms like purse-string contraction and collective crawling, highlight trade-offs between complexity and interpretability, and recommend hybrid multiscale models and stronger model–experiment integration to advance predictive tissue-repair simulations.