Interpretable XGBoost Predicts 28-Day Mortality in Sepsis ARF

Researchers led by Dr. Jian Liu published on January 10, 2026 an interpretable XGBoost model that predicts 28-day mortality for ICU patients with sepsis complicated by acute respiratory failure. They trained the model on MIMIC‑IV v3.1 and externally validated it on eICU‑CRD v2.0, selecting 20 routinely available features and using SHAP for explanation, showing stable discrimination across cohorts.