GPT-4 Generated Letters Improve Patient Discharge Comprehension

In a prospective randomized crossover study published in 2026, 48 standardized patients compared GPT-4–generated patient-centered discharge letters with standard hospital discharge letters. GPT-4 letters increased fully or partially recalled safety-relevant learning objectives (490/1073, 45.7% vs 413/1073, 38.5%; OR 1.74, 95% CI 1.45–2.08; P<.001) and reduced omissions. Improvements concentrated in medication and organizational content, with smaller effects on higher-order understanding like prevention and lifestyle.