Exposome Transforms Mental-Health Prevention Across Lifespan
In a 2026 perspective in Neuropsychopharmacology, Barzilay and Jeste argue that mapping the exposome—the lifelong external and internal environmental exposures—can improve prevention and care for mental illness. The authors outline a multidimensional framework linking physical, chemical, social, and structural exposures to biological processes, highlight sensitive life stages, and recommend ExWAS, longitudinal multi-omic designs, and EHR integration to enable precision prevention and equitable mental-health strategies.
Key Points
- 1Frames exposome as multidimensional external and internal exposures shaping mental-health risk
- 2Highlights sensitive windows like childhood, adolescence, and old age for heightened environmental influence
- 3Enables clinicians and researchers to target modifiable exposures for precision prevention and personalized care
Scoring Rationale
Synthesis of a broad, peer-reviewed framework supports research and care; limited by perspective lacking new empirical data.
Sources
Public references used for this report.
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