Engineered Heart Tissues Increase Arrhythmic Risk
Rosales et al., published April 3, 2026 in PLoS Computational Biology, use in silico simulations on nine porcine biventricular infarct models to assess arrhythmic risk after engineered heart tissue (EHT) engraftment. They report higher ventricular tachycardia inducibility for LAD and transmural infarcts, and show that implantation site, EHT conductivity, and inclusion of the ventricular conduction system materially alter VT burden. Findings underscore latent arrhythmic risk and actionable mitigations.
Scoring Rationale
Peer-reviewed, open-data computational study provides significant new, actionable insights for preclinical cardiac remuscularization. High marks for novelty, credibility, and actionability; scope is focused on porcine/preclinical models, which limits generalizability.
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Sources
- Read OriginalIn silico assessment of arrhythmic risk following the implantation of engineered heart tissues in porcine hearts with varying infarct locationsjournals.plos.org
