Digital Biomarkers Reveal Multimodal Depression Signals

Researchers from Gachon University publish a systematic review and meta-analysis (published April 2, 2026) of digital biomarkers for depression, covering 132 studies and 57,852 participants through December 28, 2025. They found statistically significant longer sleep onset latency (+4.75 minutes), increased time in bed (+31.81 minutes), and lower physical activity (SMD −0.71), but wide prediction intervals and high heterogeneity. The authors argue for personalized, multimodal digital phenotyping and standardized data protocols for reliable monitoring.
Scoring Rationale
Comprehensive, registered meta-analysis across 132 studies with robust methods and a large pooled sample, boosting novelty and credibility. Score tempered by wide between-study heterogeneity and prediction intervals that limit immediate clinical translation.
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Sources
- Read OriginalThe Role of Digital Biomarkers in Physiological Signal-Based Depression Assessment: Systematic Review and Meta-Analysisjmir.org



