DeConveil Integrates CNVs Into Differential Expression
Katsiaryna Davydzenka, Giulio Caravagna, and Guido Sanguinetti publish DeConveil on March 27, 2026 in PLoS Computational Biology, introducing a CNV-aware framework for differential gene expression analysis. Using a negative-binomial GLM, DeConveil classifies genes into dosage-sensitive, dosage-insensitive, and dosage-compensated groups across TCGA aneuploid cancers and a breast cancer case study, improving prognostic biomarker discovery and patient risk stratification compared to conventional methods.
Scoring Rationale
Strong methodological advance with open-source validation; limited by incremental novelty compared with prior CNV-aware differential-expression methods.
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Sources
- Read OriginalExtending differential gene expression testing to handle genome aneuploidy in cancerjournals.plos.org
