Researchsingle cell rna seqcardiac neuronsheart failuretranscription factors
Cardiac Neurons Reveal N4-ALK Heart Failure Subset
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Xiuqi Yang et al. (published March 20, 2026) integrate single-nucleus RNA-seq from 75 heart failure patients and 45 healthy donors to map 11,026 cardiac neurons, defining ten neuronal subsets and highlighting an N4-ALK subset enriched in failing hearts. They implicate RXRG and a PTN–PTPRZ1 signaling axis in N4-ALK neurons and develop an N4-ALK-derived machine-learning signature to identify heart failure patients.
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Strong integrative single-cell discovery with predictive signature; limited by observational design and need for experimental validation.
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