Angiography-Based FFR Matches Wire-Guided Outcomes At One-Year
Two randomized trials, ALL-RISE and FAST III, presented at the ACC and published online in the New England Journal of Medicine on March 30, 2026, found angiography-derived fractional flow reserve (FFR) noninferior to pressure wire–guided FFR for 1-year all-cause mortality, MI, or revascularization. Both systems shortened procedural time but led to higher PCI rates (~45% vs ~35%), suggesting wider adoption with caution.
Scoring Rationale
High-quality randomized trials published in NEJM and presented at ACC provide strong, industry-wide evidence for angio-derived FFR. Scored high for novelty, scope, actionability, and credibility; modest deductions for applicability across different software and modest coverage depth.
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Sources
- Read OriginalImaging-Based FFR on Par With Wire for PCI Outcomesmedpagetoday.com
